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In the CRESTOR clinical trial programdipstick-positive proteinuria and microscopic hematuria were observed among CRESTOR treated patientsThese https://buyclomidonlaine.com findings were more frequent in patients taking CRESTOR 40 mgwhen compared to lower doses of CRESTOR or comparator HMGCoA reductase inhibitorsthough it was generally transient and was not associated with worsening renal functionAlthough the clinical significance of this finding is unknowna dose reduction should be considered for patients on CRESTOR therapy with unexplained persistent proteinuria and/or hematuria during routine urinalysis testing.

Advise females of reproductive potential of the risk to a fetusto use effective contraception during treatmentand to inform their healthcare provider of a known or suspected pregnancysee CONTRAINDICATIONS and Use in Specific Populations

Dose-Titration StudyIn an open-labelforced-titration studyhomozygous FH patientsn=40863 yearswere evaluated for their response to CRESTOR 20 to 40 mg titrated at a 6week intervalIn the overall populationthe mean LDLC reduction from baseline was 22About one-third of the patients benefited from increasing their dose from 20 mg to 40 mg with further LDL lowering of greater than 6In the 27 patients with at least a 15reduction in LDLCthe mean LDL-C reduction was 30median 28reductionAmong 13 patients with an LDLC reduction of.

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but for crestor, the rate of developing rhabdomyolysis may be higher than for other statins.

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